depends where the problem area is in the throttle range..
idle to 1/4 throttle is pilot, 1/4 to 3/4 throttle is needle and obvious the rest is mainjet..
changing the mainjet will have a small effect in the lower rev ranges, but an engine that size and your altitude should have at least a 100 main and pilot will be around 40-50. tune the pilot till you have around 1.5 - 2 turns out from closed on the mix screw.
tune the pilot first then set the needle height.. and its best to do plug chops for mainjet setting.